It contains two active ingredients, atovaquone and proguanil hydrochloride. Generic Malarone has two uses one to prevent malaria and the other is to treat malaria. Malaria is spread by the bite of an infected mosquito, which passes the malaria parasite (plasmodium falciparum) into the bloodstream. Generic Malarone prevents malaria by killing this parasite. For people who already infected with malaria, Generic Malarone also kills these parasites.